– Harnessing the convergence of exponential advances in AI, genome sequencing and DNA synthesis technologies, Dyno’s approach to enabling safe and highly efficient in vivo gene delivery accelerates the development of optimized gene therapies

– Dyno’s LEAP^SM technology achieves super-human design of capsids that perform dramatically better than all prior variants, supporting earlier in vivo validation of high-performance DNA delivery

WATERTOWN, Mass., May 9, 2024 – Dyno Therapeutics, Inc., a techbio company pioneering applications of artificial intelligence to engineer AAV capsids that expand the potential of genetic medicine, today hosted a Scientific Symposium at the 27th American Society of Gene & Cell Therapy (ASGCT) Annual Meeting being held in Baltimore, MD.

The Scientific Symposium showcased Dyno’s approach to applying artificial intelligence to engineering novel adeno-associated virus (AAV) capsids for optimized in vivo delivery. The Symposium, titled “AAV Capsid Design in the Era of AI,” covered Dyno’s approach to solving one of the most difficult challenges of gene therapy: safely and efficiently delivering therapeutic DNA to target organs within a patient’s body.

“The present AI revolution in biotech was prefaced by decades of exponential change in the tech industry which catalyzed the personal computer revolution by putting a computer on every desk in every home, then into every pocket and on every wrist. Now the convergence of exponential change in AI, genome sequencing, and DNA synthesis technologies is driving a similar trend, this time with respect to the cost of in vivo gene delivery,” said Eric Kelsic, Ph.D., Founder and Chief Executive Officer of Dyno Therapeutics.

“Today gene therapies can cost several millions of dollars per dose,” Kelsic continued. “Dyno is committed to reducing the cost of delivering therapeutic DNA down to zero, which will be key to making the next generation of transformative gene therapies even more affordable. Historical trends suggest that dramatic cost reductions will actually grow the overall gene therapy market, supporting a robust ecosystem of gene therapy developers and eventually enabling billions of patients to benefit from life-changing gene therapies.”

Using generative AI, Dyno recently increased the efficiency of capsid-mediated in vivo DNA delivery in the eye by 80-fold with the Dyno eCap™ 1 capsid, and to the brain by 100-fold with the Dyno bCap™ 1 capsid. Building on these initial successes, Kelsic shared how Dyno’s AI-powered methods achieved two breakthroughs, in Low-Shot Efficient Accelerated Performance (LEAP), and in the design of synthetic capsid serotypes:

• Capsids designed with LEAP dramatically outperformed capsids designed by humans without AI-assistance, improving in vivo delivery efficiency and potentially enabling lower manufacturing costs: Dyno developed LEAP technology to efficiently generate capsid sequences with enhanced performance beyond any of the capsids in the training data. LEAP now enables Dyno to rapidly advance better capsids into in vivo validation studies, resulting in faster engineering and more effective use of R&D resources. Vitally, LEAP also helps to bring down the cost of in vivo delivery by yielding capsids that more precisely deliver more therapeutic DNA per dollar of production cost.
• Applying AI to capsid diversification generated diverse synthetic serotypes, towards expansion of patient populations who can benefit from gene therapy: Pre-existing immunity to natural AAV capsids can make anywhere from 20-80% of gene therapy patients ineligible for treatment. Dyno’s AI-powered methods successfully designed synthetic capsids that differ substantially from natural capsid sequences while still remaining functional for production and transduction of human cell lines. These results demonstrate the potential of these AI methods to broaden the number of patients who can benefit from gene therapy using synthetic capsids for gene delivery. Growing the demand for gene therapies by increasing the size of the addressable patient population is one additional way to accelerate an exponential reduction in the cost of gene therapies, since higher product revenues enable more profits to be invested in innovation that further reduces costs, thereby enabling more patients to benefit from future therapies.

Kelsic added that these breakthroughs in applying AI to the design of high-performance biological sequences will benefit from Dyno’s collaboration with NVIDIA, announced earlier in the day. The work will help advance design capabilities for gene therapies and other sequence-based medicines with potential for transformative patient impact. The collaboration will focus on scaling Dyno’s pioneering “lab-in-the-loop” sequence design approach using NVIDIA’s optimized cloud and BioNeMo platforms.

About Dyno Therapeutics

Dyno Therapeutics is solving the in vivo gene delivery challenge while partnering with gene therapy developers to maximize patient impact. Dyno’s platform combines AI with high-throughput experimentation to accelerate the design of AAV capsids with properties that significantly outperform current in vivo gene delivery vectors, with the goal of expanding the range of diseases treatable with genetic medicines. Dyno has partnered with leading gene therapy developers, including Astellas, Novartis, Roche, and Sarepta, and is broadly open to partnering across therapeutic areas. Dyno was founded in 2018 and is located in Watertown, Massachusetts. Visit www.dynotx.com for additional information.

Media Contact:
Alice Tirard
Dyno Therapeutics
alice.tirard@dynotx.com

– The work will help advance design capabilities for gene therapies and other sequence-based medicines with potential for transformative patient impact

– The collaboration will focus on scaling Dyno’s pioneering “lab-in-the-loop” sequence design approach using NVIDIA’s optimized cloud and BioNeMo platforms

WATERTOWN, Mass., May 9, 2024 – Dyno Therapeutics today announced a collaboration with NVIDIA to leverage Dyno’s field-leading artificial intelligence (AI) and in vivo experimentation capabilities, along with the built-to-scale NVIDIA BioNeMo AI-powered drug design platform, to help advance biological sequence design.

Everything life does is controlled by biological sequences: DNA, RNA, and proteins. The capacity to design these sequences can drastically improve outcomes in healthcare and technology. Over the past decade, Dyno has pioneered an AI-powered approach to sequence design, creating some of the first in vivo-validated biologics using generative AI. Recently, Dyno’s proprietary generative AI methods yielded optimized capsid products that allow enhanced in vivo delivery of genetic therapies for Dyno’s partners, including the Dyno eCap™ 1 capsid in the eye and the Dyno bCap™ 1 capsid in the brain. Both have been validated through in vivo studies. Sequence-design algorithms become much more powerful when trained with appropriately large and diverse data sets and sufficiently fast and versatile computational resources. Dyno believes transformative sequence design capabilities can be brought within reach using its extensive proprietary datasets and the scale NVIDIA’s compute platform enables.

Dyno relies heavily on NVIDIA accelerated computing for its inference and design pipelines. NVIDIA will support the collaboration through its cloud infrastructure, software and the NVIDIA BioNeMo framework. These will enable Dyno to research and deploy advanced machine-learning models at a higher velocity for sequence design. Dyno’s machine learning scientists and engineers will work with NVIDIA AI experts to scale, enhance, and optimize Dyno’s AI-powered inference and search algorithms, serving them through NVIDIA NIM microservices and BioNeMo, both part of NVIDIA AI Enterprise.

“For billions of years, Darwinian evolution has been the world’s most powerful sequence design algorithm, but the resulting gene and genome sequences represent only a slim fraction of what we now know is possible to achieve. For decades, bioengineering progress has advanced primarily through mimicking this process in the lab. Dyno has demonstrated that a new route is possible by combining AI with high-throughput molecular experimentation in a self-reinforcing learning loop,” said Eric Kelsic, Ph.D., founder and Chief Executive Officer of Dyno Therapeutics. “Our work with NVIDIA will massively scale and improve this capability so that we can rapidly navigate sequence space at a pace matching revolutionary advances in modern computation, creating transformative medicines that help many more patients.”

“One of the greatest impacts of generative AI is its ability to revolutionize life sciences and healthcare,” said Rory Kelleher, Global Head of Business Development for Life Sciences at NVIDIA. “NVIDIA’s collaboration with Dyno will optimize and scale high-performance biological sequence design, helping to dramatically accelerate the pace of drug discovery and development.”

All patients can potentially benefit from the ability to design therapies based on biological sequences. As the diversity of life vividly displays the breadth of the sequence-based biological design space, improved sequence-design capabilities have the potential to create myriad new medicines with vast potential for life-changing impact. For this reason, Dyno was founded to apply advanced sequence design technologies to solve therapeutic challenges. Dyno’s team has been focused over the past decade on solving the challenge of in vivo delivery for genetic therapies by engineering optimized Adeno-associated virus (AAV) capsid sequences, and in doing so became a world leader in machine-guided sequence design and generative AI. The collaboration is made possible as a result of the insights and learnings generated by the Dyno team, including billions of in vivo sequence-function data points measured across millions of distinct capsid sequences, and the computational revolution being catalyzed by NVIDIA platforms.

Dyno’s team, accelerated by NVIDIA’s full-stack accelerated computing and AI expertise, will develop and apply AI models across numerous research areas including multi-property capsid optimization and design of novel AAV serotypes, while also generalizing these capabilities to a broader range of therapeutically relevant molecules. Dyno’s partners will benefit from the accelerated pace of Dyno’s research and development of new capsid products, as well as from computational capabilities that Dyno may offer to pharmaceutical partners through NVIDIA’s BioNeMo.

About Dyno Therapeutics

Dyno Therapeutics is solving the in vivo gene delivery challenge while partnering with gene therapy developers to maximize patient impact. Dyno’s platform combines AI with high-throughput experimentation to accelerate the design of AAV capsids with properties that significantly outperform current in vivo gene delivery vectors, with the goal of expanding the range of diseases treatable with genetic medicines. Dyno has partnered with leading gene therapy developers, including Astellas, Novartis, Roche, and Sarepta, and is broadly open to partnering across therapeutic areas in gene therapy and machine learning. Dyno was founded in 2018 and is located in Watertown, Massachusetts. Visit www.dynotx.com for additional information.

Media Contact:
Alice Tirard
Dyno Therapeutics
alice.tirard@dynotx.com

WATERTOWN, Mass., April 23, 2024 – Dyno Therapeutics, Inc., a techbio company pioneering applications of artificial intelligence to engineer AAV capsids that expand the potential of genetic medicine, today announced a Scientific Symposium and the presentation of three research abstracts, including one oral presentation, at the upcoming 27th Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT) being held May 7-11th, 2024 in Baltimore, Maryland. That same week Dyno Therapeutics will also be giving two talks on the theme of Machine Learning at SynBioBeta’s Global Synthetic Biology Conference held from May 6-9th, 2024 in San Jose, California.

From its inception, Dyno Therapeutics has been a leader in applying generative AI to advance the frontiers of AAV engineering. Through its AI-powered platform, the company has achieved improved gene delivery to a broad array of gene therapy targets, developing capsids to target the eye, muscle and brain. The company’s presence at both the ASGCT and SynBioBeta conferences will highlight recent successes from applying machine learning to capsid design, and explore what these applications mean for gene therapy in an era of rapid AI development.

Dyno’s ASGCT Scientific Symposium will showcase how artificial intelligence enables the design of novel capsids optimized across multiple in vivo delivery properties, and furthermore makes it possible to create synthetic capsids with high-edit distances from natural serotypes, thereby potentially allowing more patients to benefit from gene therapies. At SynBioBeta, Dyno engineers will delve into the reality of ML-driven approaches, highlighting both the promise and challenges that arise when solving real-world problems like in vivo delivery for gene therapies via capsid design.

ASGCT Dyno Scientific Symposium

Title: “AAV Capsid Design in the Era of Artificial Intelligence”
Presenter: Eric Kelsic, Ph.D., Founder and CEO, Dyno Therapeutics
Date and Time: May 9th 12:15 – 13:15 EDT
Location: Baltimore Convention Center, Room 309-310

ASGCT Research Abstracts

Oral Presentation: Applying Artificial Intelligence to Multi-Property Optimization of AAV Capsids for Neuronal Gene Delivery
Date and Time: May 10th, 2024 17:00 – 17:15 EDT
Location: Baltimore Convention Center, Ballroom 4
Abstract: #301

Poster Presentation: Non-Human Primate Evaluation of an Engineered AAV Capsid for Retinal Cell-Specific and Biofactory-Based Ocular Gene Therapies
Date and Time: May 8th, 2024 12:00 – 19:00 EDT
Abstract: #516

Poster Presentation: Expanding the Serotype Frontier: Design of Synthetic AAV Capsids with Artificial Intelligence
Date and Time: May 10th, 2024 12:00 – 19:00 EDT
Abstract: #1465

SynBioBeta Global Synthetic Biology Conference

Oral Presentation: AI-Designed Capsids: Powering a New Age of Genetic Medicine
Date and Time: May 8th, 2024, 11:00 – 11:45 PDT
Location: San Jose Convention Center, Main Stage – Grand Ballroom 220A

Lunch & Learn: Generative AI is Not Enough: Bridging In-Silico to Impact—Where Hype Faces Reality
Date and Time: May 9th, 2024, 12:15 – 13:00 PDT
Location: San Jose Convention Center, Meeting Room 212B

About Dyno Therapeutics

Dyno Therapeutics is solving the in vivo gene delivery challenge while partnering with gene therapy developers towards maximizing patient impact. Dyno’s platform combines AI with high-throughput experimentation to accelerate the design of AAV capsids with properties that significantly outperform current in vivo gene delivery vectors, with the goal of expanding the range of diseases treatable with genetic medicines. Dyno has partnered with leading gene therapy developers, including Astellas, Novartis, Roche, and Sarepta, and is broadly open to partnering across therapeutic areas. Dyno was founded in 2018 and is located in Watertown, Massachusetts. Visit www.dynotx.com for additional information.

Media Contact:
Alice Tirard
Dyno Therapeutics
alice.tirard@dynotx.com

– Dyno bCap 1 exhibits 100x improvement versus AAV9 in delivery to the central nervous system (CNS) and 10x detargeting of liver after intravenous (IV) dosing, as characterized across multiple non-human primate (NHP) species –

– Compared head-to-head with other capsids engineered for CNS-IV delivery, Dyno bCap 1 performs significantly better overall in delivery to the CNS, liver detargeting, and production efficiency –

– The Dyno bCap 1 product and other proprietary capsids for CNS-IV delivery are available for immediate licensing to partners developing optimized gene therapies –

WATERTOWN, Mass., May 19, 2023 – Dyno Therapeutics, Inc., a techbio company pioneering applications of artificial intelligence to engineer AAV capsids that can expand the potential of genetic medicine, today announced the launch of its Dyno bCap 1™ capsid product, a breakthrough CNS-targeted AAV gene delivery vector with best-in-class potential, in a keynote address at the company’s Scientific Symposium at the American Society of Gene & Cell Therapy (ASGCT) 26^th Annual Meeting. The Dyno bCap 1 vector provides dramatically improved CNS delivery and liver detargeting compared to leading natural capsids and stronger all-around characteristics relative to other engineered CNS-IV capsids.

“Safe and effective gene delivery to the brain is a primary factor limiting the treatment of CNS diseases with gene therapy today. We believe effective delivery to all cells throughout the brain will unlock the potential to treat patients affected by a variety of genetic diseases, including amyotrophic lateral sclerosis, Angelman syndrome, Parkinson’s disease and Alzheimer’s disease,” said Adrian Veres, M.D., Ph.D., CSO and Co-founder of Dyno. “We look forward to further exploring the transformative potential of Dyno bCap 1, as well as our growing line of capsid products, by partnering with leading developers of gene therapies.”

To create high-performing capsids, Dyno has pioneered the application of state-of-the-art methods in deep learning and generative artificial intelligence (AI) to protein sequence design, while also leveraging large, internally collected in vivo datasets that provide high-resolution insights into the many therapeutically relevant capsid delivery properties. By combining AI and high-throughput biology, Dyno’s platform is capable of more fully exploring the AAV capsid sequence space in search of capsids that are optimized across multiple dimensions, such as CNS targeting, liver detargeting, and production efficiency. As a result, the protein sequence for the Dyno bCap 1 product is highly novel, with a pattern of sequence changes that would not occur using methods most typically used for engineering AAV capsids, such as random mutation or insertion of short peptides in the capsid protein sequence. After AI-driven design of the capsid sequence, Dyno extensively characterized the in vivo delivery properties of Dyno bCap 1 across species in NHPs, the most relevant animal models for translation to humans.

Key Data on Dyno bCap 1 Technology

• Relative to the commonly used AAV9 capsid, Dyno bCap1 exhibits 100-fold better pan-brain CNS transduction upon crossing of the blood-brain barrier and 10-fold better liver detargeting.
• Dyno bCap1 improvements in transduction and targeting specificity are conserved across NHP species in both cynomolgus monkey (Macaca fascicularis) and African green monkey (Chlorocebus sabaeus), increasing confidence that the breakthrough CNS delivery capabilities of Dyno bCap 1 could be relevant for applications in human therapeutics.
• Whereas naturally-derived capsids such as AAV9 transduce only a small fraction of brain cells in NHPs, with a low IV injected dose of 1e13vg/kg, payloads delivered by the Dyno bCap 1 capsid transduced between 4-14% of cells in the brain, and 5-20% of neurons across pan-brain regions and the spinal cord, potentially broadening the diseases which can be successfully treated with gene therapy.
• Compared in library format head-to-head against an external engineered AAV capsid reported to have improved brain transduction relative to other CNS-IV capsids, Dyno bCap 1 demonstrated consistent brain transduction across animals, with comparable or improved transduction relative to the external capsid, and dramatically better production efficiency, demonstrating the transformative potential of Dyno bCap 1 for CNS-IV delivery.

Licensing Dyno bCap 1 Technology
Dyno Therapeutics is making Dyno bCap 1 technology and additional proprietary capsids with improved CNS delivery properties available immediately for licensing to gene therapy developers across academia and industry.

“Dyno’s business is partnership-centric: We partner with gene therapy developers, providing them with the very best capsids so that they can invest their efforts at the leading edge of genetic medicine,” said Dyno CEO and Co-founder, Eric Kelsic, Ph.D. “With the Dyno bCap1 launch, we are delivering on this promise for our partners, both existing and to come. We’re ready to build new partnering relationships in the CNS and beyond that will enable our industry to realize the potential of genetic medicines to help patients in need all around the world.”

About Dyno Therapeutics
Dyno Therapeutics is solving the in vivo gene delivery challenge while broadly partnering with gene therapy developers towards maximizing patient impact. Dyno’s platform combines AI with high-throughput experimentation to accelerate the design of AAV capsids with properties that significantly outperform current in vivo gene delivery vectors, with the goal of expanding the range of diseases treatable with genetic medicines. Dyno has partnered with leading gene therapy developers, including Astellas, Novartis, Roche, and Sarepta, and is broadly open to partnering across therapeutic areas. Dyno was founded in 2018 and is located in Watertown, Massachusetts. Visit www.dynotx.com for additional information.

Media Contact:
Rhiannon Jeselonis
Ten Bridge Communications
rhiannon@tenbridgecommunications.com

 

WATERTOWN, Mass., May 2, 2023 – Dyno Therapeutics, Inc., a techbio company pioneering applications of artificial intelligence to engineering AAV capsids that can expand the potential of genetic medicine, today announced a Dyno Scientific Symposium and the presentation of four research abstracts at the upcoming 26^th Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT) being held May 16-20, 2023 in Los Angeles, Calif.

Among the results to be presented is a breakthrough in CNS delivery: Dyno’s AI-guided design and subsequent in vivo characterization of a novel AAV capsid that delivers genetic payloads to a significant and potentially therapeutically relevant fraction of neurons across the central nervous system (CNS), including deep brain structures, via IV administration in non-human primates.

Dyno Scientific Symposium
Title: “The Capsids You Need: AI-Guided Design and In Vivo Validation of AAV Capsids for Better Delivery to Muscle, Eye and CNS”
Date and Time: Friday, May 19 from 12:00-1:30 p.m. PT
Location: Petree Hall C

Dyno’s scientific symposium will describe the transformative properties of Dyno’s license-ready capsids across therapeutic areas, including a breakthrough in CNS delivery aided by generative AI.

Dyno is leveraging its platform to additionally design optimized capsids for muscle and eye delivery, towards significantly expanding the potential of genetic medicine.

Symposium speakers:
Eric Kelsic, Ph.D., CEO and Co-founder
Adrian Veres, Ph.D., CSO and Co-founder
Jamie Kwasknieski, Ph.D., Head of Platform
Yvette Leung, MBA, Head of Corporate Development

Research abstracts showcasing Dyno’s capsids:
Title: “Crossing the Non-Human Primate Blood Brain Barrier with Machine-Guided AAV Capsid Design”
Date and Time: Wednesday, May 17 at 12:00 p.m. PT
Poster/Abstract Number: 382

Title: “Optimizing Intravitreal Delivery to the Non-Human Primate Retina with Machine-Guided AAV Capsid Design”
Date and Time: Friday, May 19 at 12:00 p.m. PT
Poster/Abstract Number: 1284

Research abstracts featuring Dyno’s platform capabilities:
Title: “A Robust Machine Learning Algorithm for Improving AAV Capsid Performance”
Date and Time: Wednesday, May 17 at 12:00 p.m. PT
Poster/Abstract Number: 467

Title: “Automated Micro-TFF System Streamlines Purification and Operator Time in a Lean rAAV Manufacturing Operation”
Date and Time: Thursday, May 18 at 12:00 p.m. PT
Poster/Abstract Number: 887

Pre-meeting workshop and panel discussion:
Title: “Building the team that’s right for your startup”
Speaker: Eric Kelsic, PhD, CEO and Co-founder
Date and Time: Tuesday May 16, at 9:40 a.m PT, Concourse Hall 150 & 151
Session: The Magic Year – Founders tips for what to do in your last six months of academia and first six months in industry

About Dyno Therapeutics
Dyno Therapeutics is solving the in vivo gene delivery challenge while broadly partnering with gene therapy developers towards maximizing patient impact. Dyno’s platform combines artificial intelligence (AI) with high-throughput experimentation to accelerate the design of AAV capsids with properties that significantly outperform current in vivo gene delivery vectors, towards expanding the range of diseases treatable with genetic medicines. To date, Dyno has partnered with leading gene therapy developers, including Astellas, Novartis, Roche, Sarepta and is broadly open to partnering across therapeutic areas. Dyno was founded in 2018 and is located in Watertown, Massachusetts. Visit www.dynotx.com for additional information.

Media Contact:
Rhiannon Jeselonis
Ten Bridge Communications
rhiannon@tenbrigecommunications.com

Cloud native tools such as Kubernetes and Argo Workflows are improving productivity, accelerating innovation, and increasing operational efficiency. These tools reduce the burden of infrastructure management by enabling efficient and scalable management of complex computing tasks.

At Dyno Therapeutics, we have not only built a proprietary engine that leverages Kubernetes and Argo Workflows for our ML-guided design of AAV capsids, but we have also contributed to the open source community by developing and releasing Hera. Hera is a project that simplifies access to Argo Workflows, and we use it to design and execute complex workflows for vector design, biological data processing, and large scale data ingestion.

To learn more about how we’re leveraging the Cloud Native Computing Foundation ecosystem to scale our gene therapy research efforts at Dyno Therapeutics, check out our abstract and full talk below on “Scaling Gene Therapy Research with Argo Workflows and Hera” from ArgoCon 2023.

Abstract:
The use of cloud native tools such as Kubernetes and Argo Workflows is becoming increasingly popular across various domains, including gene therapy. These tools enable efficient and scalable management of complex computing tasks, allowing researchers and engineers to focus on their core product rather than infrastructure management. This has led to improved productivity, increased innovation, and increased operational efficiency. At Dyno Therapeutics, we use our proprietary engine called Dynet to generate and consume massive amounts of data to design and test vectors used for the delivery of gene therapy. Dyno leverages Kubernetes, Argo Workflows, and Hera to define, orchestrate, and execute complex workflows used for vector design, biological data processing, and large scale data ingestion. This talk will showcase novel applications of Argo Workflows and Kubernetes from a field as novel as gene therapy, and illustrate how tech products, such as Hera, from the Cloud Native Computing Foundation ecosystem help scale gene therapy research and engineering efforts.

Full talk: https://www.youtube.com/watch?v=h2TEw8kd1Ds&t=1s&ab_channel=CNCF%5BCloudNativeComputingFoundation%5D

BOSTON, MA — April 25, 2023— We are pleased to announce the promotion of Adam Poulin-Kerstien, JD, PhD to General Counsel & appointment of Adrian Veres, MD, PhD to Chief Scientific Officer!

Adam Poulin-Kerstien, JD, PhD, has extensive experience as a life sciences intellectual property and corporate attorney. While at Dyno, Adam defined Dyno’s IP strategy and supported Dyno’s broader legal needs as Head of Legal and member of the executive leadership team. Prior to joining Dyno, Adam worked for the Novartis Institutes for Biomedical Research where he led and coordinated IP support for Novartis’ respiratory disease and neuroscience research and development programs. Adam holds a BA in Chemistry from Amherst College, a PhD from Caltech, and a JD from UCLA School of Law.

Adrian Veres, MD, PhD is happiest combining experimental and computational biology to solve critical problems in developing the next generation of human medicines. As Dyno co-founder, his past roles include Head of People and Head of R&D. Adrian holds an A.B. in Physics and Chemistry from Harvard College, a PhD in Systems Biology from Harvard University and an MD with Honors from Harvard & MIT.

Adam and Adrian, we look forward to your leadership as we advance the frontiers of #genetherapy to transform patient lives with cutting-edge science!

About Dyno Therapeutics

Dyno Therapeutics is a pioneer in applying artificial intelligence (AI) and quantitative in vivo experiments to gene therapy. The company’s proprietary CapsidMap™ platform rapidly discovers and systematically optimizes Adeno-Associated Virus (AAV) capsid vectors that significantly outperform current approaches for in vivo gene delivery, thereby expanding the range of diseases treatable with gene therapies. Dyno was founded in 2018 by experienced biotech entrepreneurs and leading scientists in the fields of gene therapy and machine learning. The company is located in Cambridge, Massachusetts. Visit www.dynotx.com for additional information.

BOSTON, MA — March 11, 2022— Dyno Therapeutics is pleased to announce it has been recognized on the Forbes list of America’s Best Startup Employers 2022. This prestigious award is presented by Forbes and Statista Inc., the world-leading statistics portal and industry ranking provider, to the top 500 companies in the U.S.

America’s Best Startup Employers were selected by evaluating:

• Employee satisfaction
• Employer reputation
• Company growth

Dyno is looking for dynamic and driven high-potential problem-solvers to support the optimization of AAV gene therapies to transform patient lives with cutting-edge science. Interested in becoming an AAViator and joining our team? Visit www.dynotx.com/careers to see all open positions.

 

About Dyno Therapeutics

Dyno Therapeutics is a pioneer in applying artificial intelligence (AI) and quantitative in vivo experiments to gene therapy. The company’s proprietary CapsidMap™ platform rapidly discovers and systematically optimizes Adeno-Associated Virus (AAV) capsid vectors that significantly outperform current approaches for in vivo gene delivery, thereby expanding the range of diseases treatable with gene therapies. Dyno was founded in 2018 by experienced biotech entrepreneurs and leading scientists in the fields of gene therapy and machine learning. The company is located in Cambridge, Massachusetts. Visit www.dynotx.com for additional information.

Discussing the Convergence of Biotechnology and Technology 

Boston, Dec. 9, 2021 – Dyno Therapeutics announced today that management is scheduled to participate at the Goldman Sachs Byte-ology Conference.

Dyno’s mission is to build the ideal capsid and solve the challenges of vivo gene delivery. Our data driven approach is a key enabler and differentiator. Dyno’s CapsidMap Platform is building the world’s most informative and diverse library of capsid measurements, and an algorithm that learns to efficiently explore sequence space in search of the best capsids for therapeutic delivery.

Tune in today at 11:00 ET to catch Eric Kelsic, CEO and co-founder: Click Here for Webcast

 

BOSTON, MA — December 6, 2021— Dyno Therapeutics has announced it was selected for the Emerging Company of the Year Award in the Life Sciences Category at the ninth annual NEVY Awards by the New England Venture Capital Association (NEVCA). The awards recognize and celebrate the top innovators, investors and companies in the region. The theme this year highlighted the “heroes” of New England’s innovation ecosystem—the entrepreneurs and investors committed to leveraging science and technology for a better tomorrow. Presented again this year by Dell Technologies, winners were announced both live and in-person at House of Blues Boston and streamed virtually. 

“Dyno has a pioneering artificial intelligence (AI) led approach to solving gene therapy’s biggest challenge: the efficient, safe and precise gene delivery to target tissues,” said Eric Kelsic, PhD, chief executive officer and co-founder of Dyno Therapeutics. “We are honored to receive this recognition from NEVCA as Emerging Company of 2021 for the Life Sciences. Thanks to all AAViators for making this possible  through Collective Innovation: empowering a  diverse team of the best problem solvers to drive cutting-edge science towards improving patient health.” 

The NEVYs honor both early- and late-stage companies, as well as the venture capitalists who support them, and cover a broad spectrum of the region’s thriving industry clusters. The academies are broken out across Life Sciences, Healthcare, Climate Tech, MedTech and Technology.

“It was wonderful to celebrate our NEVYs award ceremony both in-person and virtually to honor the heroic companies and investors working to fortify the innovation in New England and beyond,” said NEVCA President, Jody Rose. “Those in our venture community are building a brighter and bolder future for all of us. Congratulations to the winners and nominees!”

Dyno Therapeutics joins an impressive list of outstanding companies from around New England, in categories across the innovation landscape.

The winners of the 2021 NEVY Awards in the Life Sciences category are:

• Patient Impact Award: Moderna
• Emerging Life Science Company of the Year: Dyno Therapeutics
• Life Science Deal of the Year: Pandion Therapeutics

The winners of the 2021 NEVY Awards in the Healthcare category are:

• Emerging Healthcare Company of the Year: FOLX Health
• Powerhouse Healthcare Company of the Year: Reify Health
• Liquidity Event of the Year: Iora Health

The winners of the 2021 NEVY Awards in the MedTech category are:

• Emerging MedTech Company of the Year: PanTher Therapeutics
• Powerhouse MedTech Company of the Year: Vicarious Surgical

The winners of the 2021 NEVY Awards in the Climate Tech category are:

• Early Company of the Year: Sublime Systems
• Powerhouse Climate Tech Company: Desktop Metal
• Rocket Ship Company of the Year: Battery Resources

The winners of the 2021 NEVY Awards in the Technology category are:

• Emerging Tech Company: Verve Motion
• Hottest Tech Startup: Perch
• Liquidity Event of the Year: Toast
• Company of the Year: Whoop

The winner of the 2021 NEVY Awards Fund of the Year was: Bessemer Venture Partners

Alongside Presenting Sponsor Dell Technologies, the 2021 NEVY Awards were supported by Abbvie, Alexandria Real Estate Equities, Deloitte, IDA Ireland, Johnson & Johnson Innovation – JJDC, JP Morgan, Matter and V2 Communications.

About Dyno Therapeutics
Dyno Therapeutics is a pioneer in applying artificial intelligence (AI) and quantitative in vivo experiments to gene therapy. The company’s proprietary CapsidMap™ platform rapidly discovers and systematically optimizes Adeno-Associated Virus (AAV) capsid vectors that significantly outperform current approaches for in vivo gene delivery, thereby expanding the range of diseases treatable with gene therapies. Dyno was founded in 2018 by experienced biotech entrepreneurs and leading scientists in the fields of gene therapy and machine learning. The company is located in Cambridge, Massachusetts. Visit www.dynotx.com for additional information.

About CapsidMap™ for Designing Optimized AAV Gene Therapies
Dyno’s CapsidMap™ platform overcomes the limitations of gene therapies on the market and under development today by optimizing capsids, the cell-targeting protein shells of Adeno-Associated Virus (AAV) vectors. Current gene therapies primarily use a small number of naturally occurring capsids that are limited by delivery efficiency, pre-existing immunity, payload size, and manufacturing challenges. CapsidMap works in two stages, first by measuring capsid properties in high-throughput using next-generation DNA library synthesis and DNA sequencing. With these vast quantities of in vivo data, CapsidMap then generates improved capsid sequences by applying advanced search algorithms that leverage machine learning. Dyno’s comprehensive map of capsid sequence space and AI‑powered tools thereby accelerate the design of AAV gene therapies towards optimizing manufacturability and applicability for treating a broader range of diseases.

 

About the New England Venture Capital Association
The New England Venture Capital Association (NEVCA) works toward a collaborative, inclusive, and prosperous innovation ecosystem. Through unique program-building, critical policy work, innovative regional marketing and dynamic local events, the NEVCA invests in the entrepreneurial ecosystem on behalf of the VC community. From celebrations (the NEVY Awards) to content series (VC Briefings and Syndicate Sessions), workforce development programs (Hack.Diversity and the Bioscience & Investor Inclusion Group) to advocacy and legislation (noncompete and immigration reform), the NEVCA is at once a network, catalyst and resource for the innovation economy.

 

Dyno Therapeutics PR Contact:

Nisha Deo
Head of Communications
Tel: +1 857 242-0593