WATERTOWN, Mass., April 23, 2024 – Dyno Therapeutics, Inc., a techbio company pioneering applications of artificial intelligence to engineer AAV capsids that expand the potential of genetic medicine, today announced a Scientific Symposium and the presentation of three research abstracts, including one oral presentation, at the upcoming 27th Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT) being held May 7-11th, 2024 in Baltimore, Maryland. That same week Dyno Therapeutics will also be giving two talks on the theme of Machine Learning at SynBioBeta’s Global Synthetic Biology Conference held from May 6-9th, 2024 in San Jose, California.

From its inception, Dyno Therapeutics has been a leader in applying generative AI to advance the frontiers of AAV engineering. Through its AI-powered platform, the company has achieved improved gene delivery to a broad array of gene therapy targets, developing capsids to target the eye, muscle and brain. The company’s presence at both the ASGCT and SynBioBeta conferences will highlight recent successes from applying machine learning to capsid design, and explore what these applications mean for gene therapy in an era of rapid AI development.

Dyno’s ASGCT Scientific Symposium will showcase how artificial intelligence enables the design of novel capsids optimized across multiple in vivo delivery properties, and furthermore makes it possible to create synthetic capsids with high-edit distances from natural serotypes, thereby potentially allowing more patients to benefit from gene therapies. At SynBioBeta, Dyno engineers will delve into the reality of ML-driven approaches, highlighting both the promise and challenges that arise when solving real-world problems like in vivo delivery for gene therapies via capsid design.

ASGCT Dyno Scientific Symposium

Title: “AAV Capsid Design in the Era of Artificial Intelligence”
Presenter: Eric Kelsic, Ph.D., Founder and CEO, Dyno Therapeutics
Date and Time: May 9th 12:15 – 13:15 EDT
Location: Baltimore Convention Center, Room 309-310

ASGCT Research Abstracts

Oral Presentation: Applying Artificial Intelligence to Multi-Property Optimization of AAV Capsids for Neuronal Gene Delivery
Date and Time: May 10th, 2024 17:00 – 17:15 EDT
Location: Baltimore Convention Center, Ballroom 4
Abstract: #301

Poster Presentation: Non-Human Primate Evaluation of an Engineered AAV Capsid for Retinal Cell-Specific and Biofactory-Based Ocular Gene Therapies
Date and Time: May 8th, 2024 12:00 – 19:00 EDT
Abstract: #516

Poster Presentation: Expanding the Serotype Frontier: Design of Synthetic AAV Capsids with Artificial Intelligence
Date and Time: May 10th, 2024 12:00 – 19:00 EDT
Abstract: #1465

SynBioBeta Global Synthetic Biology Conference

Oral Presentation: AI-Designed Capsids: Powering a New Age of Genetic Medicine
Date and Time: May 8th, 2024, 11:00 – 11:45 PDT
Location: San Jose Convention Center, Main Stage – Grand Ballroom 220A

Lunch & Learn: Generative AI is Not Enough: Bridging In-Silico to Impact—Where Hype Faces Reality
Date and Time: May 9th, 2024, 12:15 – 13:00 PDT
Location: San Jose Convention Center, Meeting Room 212B

About Dyno Therapeutics

Dyno Therapeutics is solving the in vivo gene delivery challenge while partnering with gene therapy developers towards maximizing patient impact. Dyno’s platform combines AI with high-throughput experimentation to accelerate the design of AAV capsids with properties that significantly outperform current in vivo gene delivery vectors, with the goal of expanding the range of diseases treatable with genetic medicines. Dyno has partnered with leading gene therapy developers, including Astellas, Novartis, Roche, and Sarepta, and is broadly open to partnering across therapeutic areas. Dyno was founded in 2018 and is located in Watertown, Massachusetts. Visit www.dynotx.com for additional information.

Media Contact:
Alice Tirard
Dyno Therapeutics
alice.tirard@dynotx.com

– 80x improvement vs. AAV2 in delivery to the retina seen in non-human primate (NHP) –

– Head-to-head against other retina-IVT capsids, Dyno eCap 1 capsid significantly outperforms in delivery to all major cell types in the retina –

– Dyno eCap 1 product and other proprietary capsids for IVT delivery are available for licensing to partners developing optimized gene therapies –

WATERTOWN, Mass., Oct 25, 2023 – Dyno Therapeutics, Inc., a techbio company pioneering applications of artificial intelligence to engineer AAV capsids that can expand the potential of genetic medicine, today announced the launch of its Dyno eCap 1™ capsid product, a leading eye AAV gene delivery vector with best-in-class potential, in a keynote address at the company’s Scientific Symposium at the 30th Annual Congress of the European Society of Gene & Cell Therapy (ESGCT). The Dyno eCap 1 vector provides significantly improved delivery to the eye compared to other externally engineered capsids, including transduction throughout multiple layers of the retina.

“Enabling effective delivery to all cells in the eye, and in particular across the entire retina, is crucial to enable gene therapies to treat ocular diseases such as wet age-related macular degeneration (wAMD), geographic atrophy, and retinitis pigmentosa,” said Adrian Veres, M.D., Ph.D., Chief Scientific Officer and Co-founder of Dyno. “The Dyno eCap 1 vector is accelerating the next generation of ocular gene therapies for both genetic and non-genetic diseases, joining our growing suite of leading-edge capsids ready to help our partners bring the world’s best gene therapies into the clinic to help more patients.”

Dyno creates highly optimized delivery vectors by deploying a pioneering machine-guided approach. This approach combines state-of-the-art methods in machine learning and generative artificial intelligence (AI) for protein sequence design, in combination with large, internally collected in vivo datasets that provide high-resolution insights into numerous relevant capsid delivery properties. To engineer its state-of-the-art capsids for ocular gene delivery, Dyno conducted robust measurement of transduction as well as spatial localization across hundreds of thousands of capsid sequences, mapping the multi-modal properties of the ocular capsid sequence space from which the Dyno eCap 1 vector could be identified. This field-leading capsid displays consistent high performance for retinal transduction across retinal layers and cell types when delivered via intravitreal injection, a common non-surgical route of administration.

Key Data on Dyno eCap 1 Technology

• The Dyno eCap 1 vector exhibits 80-fold better transduction to the retina compared to the commonly used AAV2 capsid.
• The Dyno eCap 1 vector transduces the retina better than a cohort of external engineered IVT capsids, supporting a field-leading profile.
• The Dyno eCap 1 vector consistently transduces cell types broadly across retinal layers, including rod cel, bipolar cells and retinal ganglion cells.
• The Dyno eCap 1 vector was validated in cynomolgus monkey (Macaca fascicularis), the most relevant NHP model for predicting translatability to human clinical trials. Improved performance is highly consistent across bulk RNA-seq, single-cell RNA-seq and histology.

“At Dyno, we are dedicated to realizing the full potential of gene therapy by helping our partners solve the challenge of delivering genes to every cell, every organ and every patient,” said Dyno Chief Executive Officer and Co-founder Eric Kelsic, Ph.D. “The trailblazing performance of our AI-designed capsids, as demonstrated by Dyno eCap 1 technology, continues to draw leading gene therapy developers to Dyno, so they can succeed in bringing transformative gene therapies to patients who await better treatments.”

About Dyno Therapeutics

Dyno Therapeutics is solving the in vivo gene delivery challenge while broadly partnering with gene therapy developers towards maximizing patient impact. Dyno’s platform combines AI with high-throughput experimentation to accelerate the design of AAV capsids with properties that significantly outperform current in vivo gene delivery vectors, with the goal of expanding the range of diseases treatable with genetic medicines. Dyno’s platform has attracted partnerships with leading gene therapy developers, including Astellas, Novartis, Roche, and Sarepta, and Dyno continues to be broadly open to partnering across all therapeutic areas. Dyno was founded in 2018 and is located in Watertown, Massachusetts. Visit www.dynotx.com for additional information.

Media Contact:
Lisa Raffensperger
Ten Bridge Communications
lisa@tenbridgecommunications.com

WATERTOWN, Mass., October 11, 2023 – Dyno Therapeutics, Inc., a techbio company pioneering applications of artificial intelligence to engineering AAV capsids that expand the potential of genetic medicine, today announced a Dyno Scientific Symposium and the presentation of three research abstracts at the upcoming 30^th Annual Congress of the European Society of Gene & Cell Therapy (ESGCT) being held October 24-27, 2023 in Brussels, Belgium.

Dyno Scientific Symposium:

Title: “Dyno Therapeutics: NHP-Validated Capsids for Best-in-Class Ocular and CNS Gene Delivery”
Presenter: Eric Kelsic, Ph.D., Co-founder and CEO, Dyno Therapeutics
Date and Time: Wednesday, October 25 from 13:25 to 14:25 CET
Location: Maison de la Poste

Dyno’s scientific symposium will showcase in vivo NHP data on field-leading capsids across the eye and CNS. Dyno’s AI-designed capsids significantly advance gene delivery capabilities, towards unlocking the full potential of genetic medicine.

Research abstracts showcasing Dyno’s capsids:

Title: “Dyno eCap 1 capsid: Cell-Type Resolved Validation of AAV capsids Optimized for Intravitreal Delivery to the Non-Human Primate Retina”
Date and Time: Wednesday, October 25 from 18:15 to 19:30 and Thursday, October 26 from 19:30 to 20:30 CET
Poster/Abstract Number: #P038

Title: “Dyno bCap 1 capsid: Single-Cell Characterization of CNS Transduction by Intravenously Administered AAV Capsids in Non-Human Primates”
Date and Time: Wednesday, October 25 from 18:15 to 19:30 and Thursday, October 26 from 19:30 to 20:30 CET
Poster/Abstract Number: #P012

Research abstracts featuring Dyno’s platform capabilities:

Title: “VAEprop: A Generative Machine Learning Approach for Designing High-Performing AAV Capsids for the Non-Human Primate Brain”
Date and Time: Wednesday, October 25 from 18:15 to 19:30 and Thursday, October 26 from 19:30 to 20:30 CET
Poster/Abstract Number: #P076

About Dyno Therapeutics
Dyno Therapeutics is solving the in vivo gene delivery challenge while partnering with gene therapy developers towards maximizing patient impact. Dyno’s platform combines AI with high-throughput experimentation to accelerate the design of AAV capsids with properties that significantly outperform current in vivo gene delivery vectors, with the goal of expanding the range of diseases treatable with genetic medicines. Dyno has partnered with leading gene therapy developers, including Astellas, Novartis, Roche, and Sarepta, and is broadly open to partnering across therapeutic areas. Dyno was founded in 2018 and is located in Watertown, Massachusetts. Visit www.dynotx.com for additional information.

Media Contact:
Rhiannon Jeselonis
Ten Bridge Communications
rhiannon@tenbrigecommunications.com

– Dyno bCap 1 exhibits 100x improvement versus AAV9 in delivery to the central nervous system (CNS) and 10x detargeting of liver after intravenous (IV) dosing, as characterized across multiple non-human primate (NHP) species –

– Compared head-to-head with other capsids engineered for CNS-IV delivery, Dyno bCap 1 performs significantly better overall in delivery to the CNS, liver detargeting, and production efficiency –

– The Dyno bCap 1 product and other proprietary capsids for CNS-IV delivery are available for immediate licensing to partners developing optimized gene therapies –

WATERTOWN, Mass., May 19, 2023 – Dyno Therapeutics, Inc., a techbio company pioneering applications of artificial intelligence to engineer AAV capsids that can expand the potential of genetic medicine, today announced the launch of its Dyno bCap 1™ capsid product, a breakthrough CNS-targeted AAV gene delivery vector with best-in-class potential, in a keynote address at the company’s Scientific Symposium at the American Society of Gene & Cell Therapy (ASGCT) 26^th Annual Meeting. The Dyno bCap 1 vector provides dramatically improved CNS delivery and liver detargeting compared to leading natural capsids and stronger all-around characteristics relative to other engineered CNS-IV capsids.

“Safe and effective gene delivery to the brain is a primary factor limiting the treatment of CNS diseases with gene therapy today. We believe effective delivery to all cells throughout the brain will unlock the potential to treat patients affected by a variety of genetic diseases, including amyotrophic lateral sclerosis, Angelman syndrome, Parkinson’s disease and Alzheimer’s disease,” said Adrian Veres, M.D., Ph.D., CSO and Co-founder of Dyno. “We look forward to further exploring the transformative potential of Dyno bCap 1, as well as our growing line of capsid products, by partnering with leading developers of gene therapies.”

To create high-performing capsids, Dyno has pioneered the application of state-of-the-art methods in deep learning and generative artificial intelligence (AI) to protein sequence design, while also leveraging large, internally collected in vivo datasets that provide high-resolution insights into the many therapeutically relevant capsid delivery properties. By combining AI and high-throughput biology, Dyno’s platform is capable of more fully exploring the AAV capsid sequence space in search of capsids that are optimized across multiple dimensions, such as CNS targeting, liver detargeting, and production efficiency. As a result, the protein sequence for the Dyno bCap 1 product is highly novel, with a pattern of sequence changes that would not occur using methods most typically used for engineering AAV capsids, such as random mutation or insertion of short peptides in the capsid protein sequence. After AI-driven design of the capsid sequence, Dyno extensively characterized the in vivo delivery properties of Dyno bCap 1 across species in NHPs, the most relevant animal models for translation to humans.

Key Data on Dyno bCap 1 Technology

• Relative to the commonly used AAV9 capsid, Dyno bCap1 exhibits 100-fold better pan-brain CNS transduction upon crossing of the blood-brain barrier and 10-fold better liver detargeting.
• Dyno bCap1 improvements in transduction and targeting specificity are conserved across NHP species in both cynomolgus monkey (Macaca fascicularis) and African green monkey (Chlorocebus sabaeus), increasing confidence that the breakthrough CNS delivery capabilities of Dyno bCap 1 could be relevant for applications in human therapeutics.
• Whereas naturally-derived capsids such as AAV9 transduce only a small fraction of brain cells in NHPs, with a low IV injected dose of 1e13vg/kg, payloads delivered by the Dyno bCap 1 capsid transduced between 4-14% of cells in the brain, and 5-20% of neurons across pan-brain regions and the spinal cord, potentially broadening the diseases which can be successfully treated with gene therapy.
• Compared in library format head-to-head against an external engineered AAV capsid reported to have improved brain transduction relative to other CNS-IV capsids, Dyno bCap 1 demonstrated consistent brain transduction across animals, with comparable or improved transduction relative to the external capsid, and dramatically better production efficiency, demonstrating the transformative potential of Dyno bCap 1 for CNS-IV delivery.

Licensing Dyno bCap 1 Technology
Dyno Therapeutics is making Dyno bCap 1 technology and additional proprietary capsids with improved CNS delivery properties available immediately for licensing to gene therapy developers across academia and industry.

“Dyno’s business is partnership-centric: We partner with gene therapy developers, providing them with the very best capsids so that they can invest their efforts at the leading edge of genetic medicine,” said Dyno CEO and Co-founder, Eric Kelsic, Ph.D. “With the Dyno bCap1 launch, we are delivering on this promise for our partners, both existing and to come. We’re ready to build new partnering relationships in the CNS and beyond that will enable our industry to realize the potential of genetic medicines to help patients in need all around the world.”

About Dyno Therapeutics
Dyno Therapeutics is solving the in vivo gene delivery challenge while broadly partnering with gene therapy developers towards maximizing patient impact. Dyno’s platform combines AI with high-throughput experimentation to accelerate the design of AAV capsids with properties that significantly outperform current in vivo gene delivery vectors, with the goal of expanding the range of diseases treatable with genetic medicines. Dyno has partnered with leading gene therapy developers, including Astellas, Novartis, Roche, and Sarepta, and is broadly open to partnering across therapeutic areas. Dyno was founded in 2018 and is located in Watertown, Massachusetts. Visit www.dynotx.com for additional information.

Media Contact:
Rhiannon Jeselonis
Ten Bridge Communications
rhiannon@tenbridgecommunications.com

 

WATERTOWN, Mass., May 2, 2023 – Dyno Therapeutics, Inc., a techbio company pioneering applications of artificial intelligence to engineering AAV capsids that can expand the potential of genetic medicine, today announced a Dyno Scientific Symposium and the presentation of four research abstracts at the upcoming 26^th Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT) being held May 16-20, 2023 in Los Angeles, Calif.

Among the results to be presented is a breakthrough in CNS delivery: Dyno’s AI-guided design and subsequent in vivo characterization of a novel AAV capsid that delivers genetic payloads to a significant and potentially therapeutically relevant fraction of neurons across the central nervous system (CNS), including deep brain structures, via IV administration in non-human primates.

Dyno Scientific Symposium
Title: “The Capsids You Need: AI-Guided Design and In Vivo Validation of AAV Capsids for Better Delivery to Muscle, Eye and CNS”
Date and Time: Friday, May 19 from 12:00-1:30 p.m. PT
Location: Petree Hall C

Dyno’s scientific symposium will describe the transformative properties of Dyno’s license-ready capsids across therapeutic areas, including a breakthrough in CNS delivery aided by generative AI.

Dyno is leveraging its platform to additionally design optimized capsids for muscle and eye delivery, towards significantly expanding the potential of genetic medicine.

Symposium speakers:
Eric Kelsic, Ph.D., CEO and Co-founder
Adrian Veres, Ph.D., CSO and Co-founder
Jamie Kwasknieski, Ph.D., Head of Platform
Yvette Leung, MBA, Head of Corporate Development

Research abstracts showcasing Dyno’s capsids:
Title: “Crossing the Non-Human Primate Blood Brain Barrier with Machine-Guided AAV Capsid Design”
Date and Time: Wednesday, May 17 at 12:00 p.m. PT
Poster/Abstract Number: 382

Title: “Optimizing Intravitreal Delivery to the Non-Human Primate Retina with Machine-Guided AAV Capsid Design”
Date and Time: Friday, May 19 at 12:00 p.m. PT
Poster/Abstract Number: 1284

Research abstracts featuring Dyno’s platform capabilities:
Title: “A Robust Machine Learning Algorithm for Improving AAV Capsid Performance”
Date and Time: Wednesday, May 17 at 12:00 p.m. PT
Poster/Abstract Number: 467

Title: “Automated Micro-TFF System Streamlines Purification and Operator Time in a Lean rAAV Manufacturing Operation”
Date and Time: Thursday, May 18 at 12:00 p.m. PT
Poster/Abstract Number: 887

Pre-meeting workshop and panel discussion:
Title: “Building the team that’s right for your startup”
Speaker: Eric Kelsic, PhD, CEO and Co-founder
Date and Time: Tuesday May 16, at 9:40 a.m PT, Concourse Hall 150 & 151
Session: The Magic Year – Founders tips for what to do in your last six months of academia and first six months in industry

About Dyno Therapeutics
Dyno Therapeutics is solving the in vivo gene delivery challenge while broadly partnering with gene therapy developers towards maximizing patient impact. Dyno’s platform combines artificial intelligence (AI) with high-throughput experimentation to accelerate the design of AAV capsids with properties that significantly outperform current in vivo gene delivery vectors, towards expanding the range of diseases treatable with genetic medicines. To date, Dyno has partnered with leading gene therapy developers, including Astellas, Novartis, Roche, Sarepta and is broadly open to partnering across therapeutic areas. Dyno was founded in 2018 and is located in Watertown, Massachusetts. Visit www.dynotx.com for additional information.

Media Contact:
Rhiannon Jeselonis
Ten Bridge Communications
rhiannon@tenbrigecommunications.com

BOSTON, MA — March 11, 2022— Dyno Therapeutics is pleased to announce it has been recognized on the Forbes list of America’s Best Startup Employers 2022. This prestigious award is presented by Forbes and Statista Inc., the world-leading statistics portal and industry ranking provider, to the top 500 companies in the U.S.

America’s Best Startup Employers were selected by evaluating:

• Employee satisfaction
• Employer reputation
• Company growth

Dyno is looking for dynamic and driven high-potential problem-solvers to support the optimization of AAV gene therapies to transform patient lives with cutting-edge science. Interested in becoming an AAViator and joining our team? Visit www.dynotx.com/careers to see all open positions.

 

About Dyno Therapeutics

Dyno Therapeutics is a pioneer in applying artificial intelligence (AI) and quantitative in vivo experiments to gene therapy. The company’s proprietary CapsidMap™ platform rapidly discovers and systematically optimizes Adeno-Associated Virus (AAV) capsid vectors that significantly outperform current approaches for in vivo gene delivery, thereby expanding the range of diseases treatable with gene therapies. Dyno was founded in 2018 by experienced biotech entrepreneurs and leading scientists in the fields of gene therapy and machine learning. The company is located in Cambridge, Massachusetts. Visit www.dynotx.com for additional information.

Presentations describe use of in vivo screening and machine learning to accelerate the analysis, design, and validation of improved AAV vectors.

Cambridge, MA – May 11, 2021 – Dyno Therapeutics, a biotechnology company applying artificial intelligence (AI) to gene therapy, will describe ongoing enhancements to its machine learning platform in three oral presentations at the 24^th annual meeting of the American Society of Gene and Cell Therapy (ASGCT), taking place virtually from May 11-14, 2021.

Dyno’s presentations, summarized below, highlight advancements of the company’s CapsidMap™ platform that enable increased capsid design efficiency, optimized experiments for in vivo capsid validation, and improved quality of in vivo measurements.

 

Efficient design of optimized AAV capsids using multi-property machine learning models trained across cells, organs and species, Tuesday May 11, 2021 at 5:45-6:00pm EST

Machine learning models improve AAV capsid design efficiency, defined as the probability that a designed variant will have improved function. We synthesized and barcoded capsid libraries containing 803,041 designed sequence variants of three natural AAV serotypes and measured their properties as delivery vectors both in vitro and in vivo.  Single-property machine learning models trained on these data can improve the efficiency of library design by at least several hundred-fold. Furthermore, models trained on multiple properties help overcome data sparsity and measurement error, thereby improving model accuracy, and providing a more reliable interpretation of experimental results.

 

Risk-Adjusted Selection for Validation of Sequences in AAV Design Using Composite Sampling, Tuesday May 11, 2021 at 6:00-6:15pm EST

Using our machine learning models, billions of promising AAV variants can be designed and scored computationally for predicted fitness. Accurate high-throughput experimental testing is practically limited, however, to hundreds of thousands of variants. From these high-throughput measurements we must then choose on the order of hundreds of variants for more extensive experimental validation, to identify the best possible individual capsid variants.

To address this question of which capsid variants should be tested experimentally, we developed a novel optimization algorithm called Composite Sampling (CS). This algorithm reduces a pool of hundreds of thousands of variants in a way that maximizes the chances of including the best candidates in the validation set. We show the value of the method through two datasets, demonstrating that Composite Sampling is consistently better than conventional approaches for selecting high performing sequences for the validation set.

 

AAV Capsid Property Estimation Is Improved by Combining Single-Molecule ID Tags and Hierarchical Bayesian Modeling of Experimental Processes May 13, 2021 at 6:15-6:30pm EST

Data-driven capsid engineering can only be as good as the quality of the data. While our high-throughput barcoded approach to measuring capsid properties allows generation of large datasets needed to train machine learning models, measuring many capsids at once introduces biases and noise in the data. To remove these biases and noise from in vivo measurements, we built a probabilistic model of AAV packaging and transduction to allow inference of the distributions for the underlying properties being measured. This presentation will describe validation of improved property value estimates from the model in comparison to naive estimates using experimental controls.

 

More information on our presentations may be found in the ASGCT program

 

About Dyno Therapeutics

Dyno Therapeutics is a pioneer in applying artificial intelligence (AI) and quantitative in vivo experiments to gene therapy. The company’s proprietary CapsidMap™ platform rapidly discovers and systematically optimizes Adeno-Associated Virus (AAV) capsid vectors that significantly outperform current approaches for in vivo gene delivery, thereby expanding the range of diseases treatable with gene therapies. Dyno was founded in 2018 by experienced biotech entrepreneurs and leading scientists in the fields of gene therapy and machine learning. The company is located in Cambridge, Massachusetts. Visit www.dynotx.com for additional information.

Dyno is making AAV gene therapies more effective, safer, more manufacturable and applicable to more diseases, and will expand capacity to meet partnership demand

Cambridge, Mass., May 6, 2021 – Dyno Therapeutics, Inc., a biotechnology company applying artificial intelligence (AI) to gene therapy, today announced a $100 million Series A financing led by Andreessen Horowitz, with participation from a select syndicate of new investors including Casdin Capital, GV, Obvious Ventures and Lux Capital. Founding investors Polaris Partners, CRV and KdT Ventures all participated in the round. Funds from this financing will directly fund expansion of the company’s CapsidMap™ platform, which uses AI technology for the design of novel Adeno-Associated Virus (AAV) gene therapy vectors, broadening the functionality and enhancing the therapeutic impact of gene therapies developed by Dyno’s biopharmaceutical partners.

Proceeds from the financing will accelerate building Dyno’s CapsidMap platform to design improved vectors targeting liver, muscle, eye and central nervous system (CNS) disease, as well as growing into new areas of lung, heart and kidney disease. Dyno will also use the proceeds to support its multiple partnership efforts with leading gene therapy biopharmaceutical companies by growing its operations, intellectual property, business development and partner success teams. This expansion augments Dyno’s existing partnerships to develop AAV vectors for Novartis, Sarepta and Roche and builds capacity to work with many additional partners. The financing will enable Dyno to significantly increase its employee base across science, machine learning and business functions.

“Dyno’s AI-powered approach to designing gene therapy vectors has transformative potential to expand the treatment landscape for gene therapies, opening new opportunities to cure thousands of diseases for patients,” said Jorge Conde, General Partner at Andreessen Horowitz. “Up until now, gene therapies have been stymied from treating more diseases and reaching more patients due to the limitations of naturally occurring AAV vectors. The field needs improved gene delivery and is eager to discover and adopt improved AAV vectors. Dyno directly addresses and solves this challenge.”

As part of the Series A financing, Mr. Conde joins the company’s board of directors. Dyno launched in late 2018 and has funded operations to date from its seed financing and financial resources generated from partnerships with biopharmaceutical companies.

“This Series A financing accelerates our AI-powered discovery of best-in-class capsids targeting all major organs and cell types, enabling Dyno to grow our business infrastructure and establish more partnerships to become the premier developer of gene therapy vectors,” said Eric Kelsic, PhD, founder and CEO of Dyno Therapeutics. “Dyno was the first to combine machine learning with data from high-throughput in vivo experiments to optimize and accelerate the design of improved capsids for gene therapy. Our CapsidMap platform brings unprecedented scale and technical sophistication to solving in vivo delivery, the key challenge for gene therapy, making therapies more effective, safe, manufacturable and capable of benefiting more patients.”

Kelsic added, “Culturally, we’re focused on achieving what we call Collective Innovation: empowering a diverse team of the best problem solvers to drive cutting-edge science towards improving patient health. We’re delighted to welcome a group of experienced investors to our team, and excited to ramp up recruiting of diverse and driven team members to help us realize the full potential of gene therapy.”

About CapsidMap™ for Designing Optimized AAV Gene Therapies

Dyno’s CapsidMap™ platform overcomes the limitations of gene therapies on the market and under development today by optimizing capsids, the cell-targeting protein shells of Adeno-Associated Virus (AAV) vectors. Current gene therapies primarily use a small number of naturally occurring capsids that are limited by delivery efficiency, pre-existing immunity, payload size, and manufacturing challenges. CapsidMap works in two stages, first by measuring capsid properties in high-throughput using next-generation DNA library synthesis and DNA sequencing. With these vast quantities of in vivo data, CapsidMap then generates improved capsid sequences by applying advanced search algorithms that leverage machine learning. Dyno’s comprehensive map of capsid sequence space and AI‑powered tools thereby accelerate the design of AAV gene therapies with optimized properties including improved efficiency, safety, manufacturability and applicability for treating a broader range of diseases.

About Dyno Therapeutics

Dyno Therapeutics is a pioneer in applying artificial intelligence (AI) and quantitative high-throughput in vivo experiments to gene therapy. The company’s proprietary CapsidMap™ platform rapidly discovers and systematically optimizes Adeno-Associated Virus (AAV) capsid vectors that significantly outperform current approaches for in vivo gene delivery, thereby expanding the range of diseases treatable with gene therapies. Dyno was founded in 2018 by experienced biotech entrepreneurs and leading scientists in the fields of gene therapy and machine learning. The company is located in Cambridge, Massachusetts. Visit www.dynotx.com for additional information.

 

Media Contact:
Kathryn Morris, The Yates Network
914-204-6412
kathryn@theyatesnetwork.com

 

Company will deliver three oral abstracts and host an Industry Symposium

Cambridge, MA – April 27, 2021 – Dyno Therapeutics, a biotechnology company applying artificial intelligence (AI) to gene therapy, today announced that it will deliver three oral presentations and an Industry Symposium at the 24^th annual meeting of the American Society of Gene and Cell Therapy (ASGCT) being held as a virtual meeting on May 11–14, 2021.

Details for the oral presentations are as follows:

Title: Efficient Design of Optimized AAV Capsids using Multi-property Machine Learning Models Trained across Cells, Organs and Species (Abstract #23)
Presenter:  Eric Kelsic, Ph.D., CEO and Co-founder, Dyno Therapeutics
Session: Development of AAV Capsid Variants
Time: 5:45 – 6:00pm EST on Tuesday, May 11

Title: Risk-Adjusted Selection for Validation of Sequences in AAV Design Using Composite Sampling (Abstract #24)
Presenter: Lauren Wheelock, Ph.D., Scientist I, Machine Learning, Dyno Therapeutics
Session: Development of AAV Capsid Variants
Time: 6:00 – 6:15pm EST on Tuesday, May 11

Title: AAV Capsid Property Estimation Is Improved by Combining Single-Molecule
ID Tags and Hierarchical Bayesian Modeling of Experimental Processes (Abstract #190)
Presenter: Kathy Lin, Ph.D., Sr. Scientist, Computational Biology, Dyno Therapeutics
Session: Novel AAV Biology and Platform Technologies
Time: 6:15 – 6:30pm EST on Thursday, May 13

Dyno will also host an Industry Symposium entitled “Building Dyno Therapeutics” from 5:15 – 6:45pm EST on Thursday, May 13. During this interactive session, employees throughout the company will describe the breakthroughs that enabled Dyno’s approach to AAV capsid engineering, how the company is inventing new methods for machine learning and quantitative high-throughput in vivo experimentation, and the story of developing a world-class team and culture alongside groundbreaking science.

About CapsidMap™ for Designing Optimized AAV Gene Therapies

Dyno’s CapsidMap™ platform overcomes the limitations of gene therapies on the market and under development today by optimizing capsids, the cell-targeting protein shells of Adeno-Associated Virus (AAV) vectors. Current gene therapies primarily use a small number of naturally occurring capsids that are limited by delivery efficiency, pre-existing immunity, payload size, and manufacturing challenges. CapsidMap works in two stages, first by measuring capsid properties in high-throughput using next-generation DNA library synthesis and DNA sequencing. With these vast quantities of in vivo data, CapsidMap then generates improved capsid sequences by applying advanced search algorithms that leverage machine learning. Dyno’s comprehensive map of capsid sequence space and AI-powered tools thereby accelerate the design of AAV gene therapies with optimized properties including improved safety, manufacturability and applicability for treating a broader range of diseases.

About Dyno Therapeutics

Dyno Therapeutics is a pioneer in applying artificial intelligence (AI) and quantitative high-throughput in vivo experiments to gene therapy. The company’s proprietary CapsidMap™ platform rapidly discovers and systematically optimizes Adeno-Associated Virus (AAV) capsid vectors that significantly outperform current approaches for in vivo gene delivery, thereby expanding the range of diseases treatable with gene therapies. Dyno was founded in 2018 by experienced biotech entrepreneurs and leading scientists in the fields of gene therapy and machine learning. The company is located in Cambridge, Massachusetts. Visit www.dynotx.com for additional information.

Scientific leaders bring deep expertise in machine learning and AAV gene therapy

Cambridge, MA – April 26, 2021 – Dyno Therapeutics, a biotech company applying artificial intelligence (AI) to gene therapy, today announced the expansion of the company’s Scientific Advisory Board (SAB) with the addition of Debora Marks, Ph.D., of Harvard Medical School and the Broad Institute, and Nicole Paulk, Ph.D., of the University of California San Francisco. 

 

Dr. Marks and Dr. Paulk will play an instrumental role in providing scientific insight and expert guidance, complementing the company’s diverse and interdisciplinary team that is focused on applying machine learning to Adeno-Associated Virus (AAV) capsid engineering for improved gene therapy delivery. They join existing members of Dyno’s SAB, George Church, Ph.D., Robert Winthrop Professor of Genetics at Harvard Medical School and a Core Faculty member at Harvard’s Wyss Institute for Biologically Inspired Engineering, and Tomas Bjorklund, Ph.D., Associate Professor of Neuroscience at Lund University. 

 

“We are honored and delighted to welcome Professors Debora Marks and Nicole Paulk to Dyno’s SAB. These preeminent scientists bring world-leading expertise in the areas of machine learning and AAV gene therapy which will accelerate Dyno’s design of best-in-class capsids that solve unmet medical needs,” said Eric Kelsic, Ph.D., co-founder and CEO of Dyno Therapeutics. “Debora offers unique insights based on her pioneering work applying machine learning to protein structure and design. Nicole’s deep scientific expertise in AAV gene therapy research, development and manufacturing will be invaluable for guiding our platform to generate products that help millions of patients.”

Debora S. Marks, Ph.D. is an Associate Professor of Systems Biology at Harvard Medical School, and an Associate Member of the Broad Institute of Harvard and MIT. Dr. Marks has led a distinguished career in academia and industry, and is an expert in the application of machine learning algorithms for protein design and engineering. She earned her B.Sc. in Mathematics from the University of Manchester, U.K., and her Ph.D. in Mathematical Biology from Humboldt University, Germany. 

 

Dr. Debora Marks commented, “I’m very excited to start working with Dyno’s world-class team and I’m particularly impressed by Dyno’s use of machine learning as a systematic approach to solving gene therapy’s biggest challenge: efficient, safe and precise gene delivery to target tissues.”

 

Nicole Paulk, Ph.D. is an Assistant Professor of AAV Gene Therapy at the University of California San Francisco Department of Biochemistry & Biophysics. She is a pioneer in next-generation AAV gene delivery and gene editing platforms. She has developed therapies for gene repair and gene transfer for numerous rare diseases, and has applied high-throughput comparative proteomic and epigenomic approaches to address challenges in fundamental AAV biology. She earned her B.S. in Medical Microbiology from Central Washington University, and her Ph.D. in Viral Gene Therapy from Oregon Health & Science University.

 

Dr. Nicole Paulk said, “I am eager to contribute my expertise to Dyno’s efforts to design novel AAV vectors that overcome the limitations of current vectors, ultimately to expand the opportunities for gene therapy to help more patients.”

 

About Dyno Therapeutics

 

Dyno Therapeutics is a pioneer in applying artificial intelligence (AI) and quantitative high-throughput in vivo experiments to gene therapy. The company’s proprietary CapsidMap™ platform rapidly discovers and systematically optimizes Adeno-Associated Virus (AAV) capsid vectors that significantly outperform current approaches for in vivo gene delivery, thereby expanding the range of diseases treatable with gene therapies. Dyno was founded in 2018 by experienced biotech entrepreneurs and leading scientists in the fields of gene therapy and machine learning. The company is located in Cambridge, Massachusetts. Visit www.dynotx.com for additional information.